Clinical Resolution Laboratories (CRL) sells this Age Defying Liposomal Retinol Moisturizer as a nightly anti-aging treatment built around a time-released retinol delivery system.
The brand states the moisturizer uses 1% pure retinol encapsulated via a liposomal delivery system, intended to release gradually overnight to reduce the redness and flaking commonly associated with traditional retinoids. Supporting ingredients listed include sodium hyaluronate for hydration, squalane for moisture retention, Decapeptide-12 (described as helping reduce melanin production for dark-spot concerns), and stem cell extracts the brand describes as having anti-inflammatory and anti-aging properties. As with most retinol product marketing, these mechanism-of-action claims come from CRL's own formulation copy rather than independent clinical trial data specific to this product, so buyers with retinol sensitivity should still introduce the product gradually regardless of the "time-released, less irritation" framing — which the brand itself recommends, suggesting new users start at 2-3 nights per week before working up to nightly use.
A single jar is priced at $100.00, with tiered savings for multi-packs — a two-pack ("DUO") at $180.00 (10% off) and a three-pack ("TRIO+") at $240.00 (20% off). CRL also offers a subscribe-and-save option at $85.00 per shipment (15% off the standard price) versus the $100.00 one-time purchase price.
At the time of this review, the product showed a 5.0-star average across 21 reviews, marked as verified on the listing — a reasonably sized and positive sample, though as with any retinol product, individual results and tolerance will vary by skin type.
CRL specifies the product is for nightly use on face and neck only, should avoid the immediate eye area, and recommends daily SPF use alongside it — standard, sensible guidance for any retinol-containing skincare product.
See current pricing and subscription savings for this retinol moisturizer here.
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